synthesis, formulation and quality control of mebrofenin (brida) as a 99mtc-kit for cholescintigraphy [persian]
نویسندگان
چکیده
this article will review the essential chemical structure of ida derivatives and their biokinetic characteristics as the hepatobiliary agents. the article also presents the procedures of synthesis, formulation and quality control of mebrofenin (brida) as a 99mtc-radiopharmaceuticai kit which is produced in radioisotope division of n.r.c. 99mtc-brida has extremely low renal excretion and hence greater hepatic specificity. in addition, the brida is much more resistant to markedly elevated levels of bilirubin rather than the other ida's analogs.
منابع مشابه
Synthesis, formulation and quality control of Mebrofenin (BRIDA) as a 99mTc-KIT for cholescintigraphy [Persian]
This article will review the essential chemical structure of IDA derivatives and their biokinetic characteristics as the hepatobiliary agents. The article also presents the procedures of Synthesis, formulation and Quality control of mebrofenin (BRIDA) as a 99mTc-Radiopharmaceuticai kit which is produced in Radioisotope Division of N.R.C. 99mTc-BRiDA has extremely low renal excretion and h...
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The high expression of somatostatin receptors in many tumours, have made receptor scintigraphy with 111In-DTPA-Octreotide a widly used procedure in nuclear medicine. Despite its clinical success, some limitation and drawbacks of radiolabelling with 111In remain, especially those concerned with the cost, availability and physical decay properties of this radionuclide. 99mTc-EDDA/HYNIC-Tyr3...
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the high expression of somatostatin receptors in many tumours, have made receptor scintigraphy with 111in-dtpa-octreotide a widly used procedure in nuclear medicine. despite its clinical success, some limitation and drawbacks of radiolabelling with 111in remain, especially those concerned with the cost, availability and physical decay properties of this radionuclide. 99mtc-edda/hynic-tyr3-toc w...
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Somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. In this study Tyr³-Octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-BOC-hydrazinopyridine-3-carboxylic acid (BOC-HYNIC) and after deprotecting of conjugate, purification was performed wit...
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عنوان ژورنال:
iranian journal of nuclear medicineناشر: tehran university of medical sciences
ISSN 1681-2824
دوره 3
شماره 2 1995
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